Title:
PREPARATION OF RIFAMPICIN
Document Type and Number:
Japanese Patent JPS5838287
Kind Code:
A
Abstract:
PURPOSE: To obtain an antituberculous drug, rifampicin, in high yield and purity, by reacting rifamycin S with a 1,3-oxazolidine compound, and reacting the reaction product with 1-amino-4-methylpiperazine.
CONSTITUTION: 1mol or rifamycin S is made to react with 1W3.5mol, preferably 1.1W3.3mol of 1,3-oxazolidine compound of formula (R is H or lower alkyl) in the presence of an organic acid (preferably a weak acid such as acetic acid), preferably at 5.5W6.8pH and 45W55°C. The resultant reaction product is made to react with 1-amino-4-methylpiperazine at 50W90°C (the reaction completes within 1W5hr) to obtain rifampicin.
Inventors:
SASAKI KAZUYA
KAWABATA SHIYOUZOU
ISHIYAMA NOBUO
KAWABATA SHIYOUZOU
ISHIYAMA NOBUO
Application Number:
JP13559981A
Publication Date:
March 05, 1983
Filing Date:
August 31, 1981
Export Citation:
Assignee:
KAKEN KAGAKU KK
International Classes:
C07D498/08; (IPC1-7): C07D498/08
Attorney, Agent or Firm:
Takao Minami
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