Title:
POLYPHOSPHONATE CONTAINING BORON FOR TREATING LIME FORMING TUMOR
Document Type and Number:
Japanese Patent JPS5817120
Kind Code:
A
Abstract:
Boron containing polyphosphonates of the formula wherein Z is a boron-containing radical; R2 is an alkyl group containing from 1 to about 10 carbon atoms; R3 is a geminal diphosphonate or a vicinal polyphosphonate containing up to 10 phosphonic acid radicals; R4 is hydrogen, lower alkyl, amino, benzyl, halogen, hydroxyl, -CH2COOH, -CH2PO3H2, or -CH2CH2PO3H2; and the salts and esters thereof, have high affinity for calcified tissues, in particular calcific tumors. The compounds are useful in boron neutron capture therapy of such tumors.
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Inventors:
JIEEMUZU JIYON BENEDEIKUTO
Application Number:
JP11383882A
Publication Date:
February 01, 1983
Filing Date:
June 30, 1982
Export Citation:
Assignee:
PROCTER & GAMBLE
International Classes:
A61K31/69; A61K41/00; A61K51/04; A61P43/00; C07F9/38; C08G79/00; C07F9/40; C07F9/44; C07F9/6596; C08G79/02; (IPC1-7): A61K31/69; C07F9/38; C07F9/44; C08G79/04; C08G79/08
Attorney, Agent or Firm:
Kiyoshi Inomata