Title:
【発明の名称】抗炎症剤として有用な4,6-ジ-第三ブチル-5-ヒドロキシ-1,3-ピリミジンの置換されたヘテロアリール類似体
Document Type and Number:
Japanese Patent JPH06505239
Kind Code:
A
Abstract:
PCT No. PCT/US92/00442 Sec. 371 Date Jul. 1, 1993 Sec. 102(e) Date Jul. 1, 1993 PCT Filed Jan. 17, 1992 PCT Pub. No. WO92/13844 PCT Pub. Date Aug. 20, 1992.The present invention is novel compounds which are 4,6-di-tertiary-butyl-5-hydroxy-1,3-pyrimidine substituted 1,2,4- and 1,3,4-thiadiazoles and oxadiazoles, and 1,2,4-triazoles, and pharmaceutically acceptable additions and base salts thereof, pharmaceutical compositions and methods of use therefor. The invention compounds are now found to have activity as inhibitors of 5-lipoxygenase and/or cyclooxygenase providing treatment of conditions advantageously affected by such inhibition including inflammation, arthritis, pain, fever, and particularly rheumatoid arthritis, osteoarthritis, other inflammatory conditions, psoriasis, allergic diseases, asthma, inflammatory bowel disease, GI ulcers, cardiovascular conditions, including ischemic heart disease and atherosclerosis, and ischemia-induced cell damage, particularly brain damage caused by stroke. They can also be used topically for treating acne, sunburn, psoriasis, and eczema. Also included are leukotriene mediated pulmonary, gastrointestinal, inflammatory, dermatological, and cardiovascular conditions. The disclosed compounds also have potential utility as antioxidants. The preferred use is in treating inflammatory conditions. Thus, the present invention is also a pharmaceutical composition or method of manufacturing a pharmaceutical composition for the use of treating the noted conditions.
More Like This:
Inventors:
Berliotsu Tei, Thomas Lichyard
Connor, David Thomas
Costlan, Katherine Rose
Connor, David Thomas
Costlan, Katherine Rose
Application Number:
JP50476192A
Publication Date:
June 16, 1994
Filing Date:
January 17, 1992
Export Citation:
Assignee:
Warner-Lambert Company
International Classes:
A61K31/505; A61K31/506; A61P1/04; A61P9/00; A61P9/10; A61P11/00; A61P29/00; A61P43/00; C07D239/34; C07D239/36; C07D401/06; C07D413/04; C07D413/06; C07D417/04; C07D417/06; (IPC1-7): C07D401/06; C07D417/06; C07D413/06; A61K31/505
Attorney, Agent or Firm:
Chika Takagi (2 outside)