Title:
【発明の名称】ヒダントイン誘導体及びそれを有効成分とする医薬組成物
Document Type and Number:
Japanese Patent JP2764262
Kind Code:
B2
Abstract:
The present invention relates to novel hydantoin derivatives, processes for producing said hydantoin derivatives, pharmaceutical compositions containing at least one of said hydantoin derivatives as aldose reductase inhibitors and novel intermediate compounds in the synthesis of said hydantoin derivatives. The present invention is based on the selection of a hydantoin which is bonded by a sulfonyl group to various substituents at the 1-position of the hydantoin skeleton. The compounds of the present invention have a strong inhibitory activity against aldose reductase. These compounds are extremely useful for the treatment and/or prevention of various forms of diabetic complications based on the accumulation of polyol metabolites.
Inventors:
MOCHIDA SUGURU
KATO KAZUO
KATO KATSUAKI
MIWA KAZUTOMO
OKUDA JUN
KATO KAZUO
KATO KATSUAKI
MIWA KAZUTOMO
OKUDA JUN
Application Number:
JP21454987A
Publication Date:
June 11, 1998
Filing Date:
August 28, 1987
Export Citation:
Assignee:
MOCHIDA SEIYAKU KK
International Classes:
A61K31/415; A61K31/4166; C07D233/86; A61P3/08; A61P3/10; A61P13/02; A61P15/00; A61P25/02; A61P27/02; A61P27/12; A61P43/00; C07C311/06; C07C311/19; C07D213/70; C07D233/80; C07D235/28; C07D255/04; C07D261/20; C07D275/04; C07D277/64; C07D307/64; C07D307/82; C07D311/14; C07D333/34; C07D333/54; C07D333/56; C07D333/62; C07D401/12; C07D403/12; C07D405/12; C07D409/12; C07D413/12; C07D417/12; (IPC1-7): C07D233/80; A61K31/415
Domestic Patent References:
| JP6322565A |
Attorney, Agent or Firm:
Nobuo Kaida (1 person outside)