Title:
【発明の名称】イミダゾール誘導体およびそのサイトカイン阻害剤としての使用
Document Type and Number:
Japanese Patent JP3298641
Kind Code:
B2
Abstract:
Novel 2,4,5-triarylimidazole compounds of formula: wherein R1 is pyrimidinyl, optionally substituted with one or two substituents each of which is independently selected form C1-4 alkyl, halo, C1-4 alkoxy, C1-4 alkylthio, NH2, mono- or di-C1-6-alkylamino and a N-heterocyclyl ring which ring has from 5 to 7 members, and optionally contains an additional heteroatom selected from oxygen, sulfur and NR22; R2 is R8 or -OR12; R3 is -XaP(Z)(XbR13)2 or Q-(Y1)t; R4 is phenyl, naphth-1-yl or naphth-2-yl; Q is an aryl or heteroaryl group; Y1 is independently selected from hydrogen, C1-5 alkyl, halo-substituted C1-5 alkyl; R8 is hydrogen, heterocyclyl, heterocyclylalkyl or R11; R11 is C1-10 alkyl, halo-substituted C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, C3-7 cycloalkyl, C5-7 cycloalkenyl, aryl, arylalkyl, heteroaryl or heteroarylalkyl; processes for the preparation thereof, the use thereof in treating cytokine mediated diseases and pharmaceutical compositions for use in such therapy.
Inventors:
Adams, Jerry Leroy
Gallagher, Timothy Francis
Lee, John Shii
White, john richard
Gallagher, Timothy Francis
Lee, John Shii
White, john richard
Application Number:
JP51274193A
Publication Date:
July 02, 2002
Filing Date:
January 13, 1993
Export Citation:
Assignee:
SMITHKLINE BEECHAM CORPORATION
International Classes:
A61K31/4164; A61K31/44; A61K31/4427; A61K31/4433; A61K31/4439; A61K31/4545; A61K31/47; A61K31/4709; A61K31/4725; A61K31/496; A61K31/505; A61K31/506; A61K31/5377; A61P7/02; A61P9/00; A61P11/00; A61P11/06; A61P13/12; A61P17/06; A61P19/00; A61P19/02; A61P19/08; A61P19/10; A61P29/00; A61P31/10; A61P37/00; A61P37/06; A61P43/00; C07D233/56; C07D401/04; C07D401/14; C07D403/04; C07D409/14; C07D413/14; C07D417/14; (IPC1-7): C07D401/04; A61K31/4439; A61K31/4709; A61K31/506; A61P29/00; A61P43/00; C07D403/04; C07D409/14
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)