Title:
【発明の名称】合成の可変領域と改変された特異性を有する免疫グロブリン分子
Document Type and Number:
Japanese Patent JP2001526021
Kind Code:
A
Abstract:
The invention relates to modified immunoglobulin molecules in which one or more variable region residues that form intrachain disulfide bonds are substituted with amino acid residues that do not contain sulfydryl groups, such that the intrachain disulfide bond does not form. Such immunoglobulin molecules have an enhanced ability to elicit an anti-idiotype response. The invention further provides for the methods of prevention and treatment of cancer and/or infectious diseases using the modified immunoglobulins of the invention.
Inventors:
Birch, Ronald, M.
Application Number:
JP2000520811A
Publication Date:
December 18, 2001
Filing Date:
November 13, 1998
Export Citation:
Assignee:
Euro-Celtique, S.A.
International Classes:
C12N15/09; A61K39/395; A61K48/00; A61P31/00; A61P31/04; A61P31/18; A61P35/00; A61P37/02; C07K7/18; C07K16/00; C07K16/08; C07K16/12; C07K16/20; C07K16/30; C07K16/42; C12N5/10; G01N33/574; A61K38/00; A61K39/00; (IPC1-7): C12N15/09; A61K39/395; A61P31/00; A61P35/00; C07K16/08; C07K16/30; C07K16/42; C12N5/10; G01N33/574
Attorney, Agent or Firm:
Yusuke Hiraki (1 person outside)