【発明の名称】改良された抗原製剤

Japanese Patent JPS62500933

A

Antigenic preparations active against species of bacteria naturally producing Type 4 fimbriae, such as Bacteroides nodosus which causes footrot in sheep, are produced by culturing a suitable genetically engineered aerobic or facultatively anaerobic host bacterial cell such as Pseudomonas aeruginosa. The host cell contains the gene encoding the fimbrial structural subunit antigens of at least one strain of the said species of bacteria and an endogenous compatible system for the morphogenetic assembly of Type 4 fimbriae and/or the genes for the morphogenetic assembly of such fimbriae derived from a Type 4 fimbriate species. The genetically engineered host cells are cultured such that nature fimbriae are produced as extracellular structures and the fimbriae are harvested, substantially free of the host cells, for use as the antigenic preparation. In preferred embodiments of the invention the natural fimbrial subunit gene is modified to enhance expression in the new host. Antigenic preparations according to this invention have proven to be effective vaccines against footrot.

Matej, Jiyoung Stanley
Anderson, Belinda Jean
Elleman, Thomas Chillards

JP50491085A

April 16, 1987

October 31, 1985

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Commonwealth Scientific and Industrial Lisa-Chio-Ganize-Chyon
University of Sidney

C12N15/00; A61K39/02; A61K39/095; A61K39/104; A61K39/114; C07K14/005; C07K14/195; C07K14/41; C07K14/705; C12N1/20; C12N15/09; C12P21/00; C12R1/38; (IPC1-7): A61K39/02; A61K39/095; A61K39/104; A61K39/114; C07K15/04; C12N1/20; C12N15/00; C12P21/00; C12R1/38

RESEARCH IN VETERINARY SCIENCE=1982
NEW ZEALAND VETERINARY JOURNAL=1982
AMERICAN JOURNAL OF VETERINARY RESEARCH=1983

Asamura Akira

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