【発明の名称】改良したマトリックスメタロプロテアーゼ阻害剤

Japanese Patent JP2736285

B2

Compounds of the formulas (1) (2) wherein each R1 is independently H or alkyl (1-8C) and R2 is alkyl (1-8C) or wherein the proximal R1 and R2 taken together are -(CH2)p- wherein p=3-5; R3 is H or alkyl (1-4C); R4 is fused or conjugated unsubstituted or substituted bicycloaryl methylene; n is 0, 1 or 2; m is 0 or 1; and X is OR5 or NHR5, wherein R5 is H or substituted or unsubstituted alkyl (1-12C), aryl (6-12C), aryl alkyl (6-16C); or X is an amino acid residue or amide thereof; or X is the residue of a cyclic amine or heterocyclic amine; wherein R6 is H or lower alkyl (1-4C) and R7 is H, lower alkyl (1-4C) or an acyl group, and wherein -CONR3- is optionally in modified isosteric form are useful for treating conditions which are characterized by unwanted matrix metalloprotease activities.

GARAADEI RICHAADO II
GUROBERUNII DAMIAN

JP50154892A

April 02, 1998

November 21, 1991

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GARAADEI RICHAADO II
GUROBERUNII DAMIAN

A61K31/165; A61K31/195; A61K31/21; A61K31/215; A61K31/22; A61K31/27; A61K31/325; A61K31/40; A61K31/403; A61K31/404; A61K31/405; A61K31/445; A61K31/454; A61K31/47; A61K31/472; A61K31/505; A61K38/55; A61P1/04; A61P9/00; A61K31/16; A61P11/16; A61P17/00; A61P29/00; A61P35/00; A61P43/00; C07C259/06; C07C271/60; C07D209/20; C07D215/06; C07D215/12; C07D217/04; C07D217/14; C07D239/26; C07K5/06; C12N9/99; G01N33/53; G01N33/573; (IPC1-7): C07C259/06; A61K31/16; A61K31/165; A61K31/21; A61K31/27; A61K31/325; A61K31/405; A61K31/47; A61K31/505; A61K38/55; C07C271/60; C07D209/20; C07D215/12; C07D217/04; C07D239/26; C07K5/06; C12N9/99; G01N33/53; G01N33/573

JP62230757A
JP62103052A
JP59106445A
JP3130222A
JP5501864A

【文献】英国公開2207351(GB,A)
【文献】米国特許4743587(US,A)

Shusaku Yamamoto

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