NEW MATERIAL:The compound of formula I (R1 is formyl, t-butoxycarbonyl, chloroacetyl, trityl, silyl, etc.; R2 is H or hydroxy).
EXAMPLE: (5-Methyl-1,3-dioxol-2-on-4-yl)methyl 7-[D-O-(N-formyl-L-alanyl )mandelamido]-3-(5-methyl-1,3,4-thiadiazol-2-yl)thiomethyl-3-cephem-4-carboxylate.
USE: Useful as a preventive and remedy for bacteriosis for oral administration and a synthetic intermediate of the cephalosporin derivative of formula II. It has high antibacterial activity.
PREPARATION: The compound of formula I is prepared by reacting the compound of formula III or its reactive derivative with the compound of formula IVor its reactive derivative in the presence of a condensation agent such as N,N'- disubstituted-carbodiimide, etc. in a solvent such as acetone, etc.
TAMAKI SATOSHI
KAKEYA SENJI
KITAO KAZUHIKO
| JPS5273895A | 1977-06-21 | |||
| JPS4711273A | ||||
| JPS57142988A | 1982-09-03 | |||
| JPS5869876A | 1983-04-26 | |||
| JPS59116292A | 1984-07-05 |