Title:
【発明の名称】コルチコステロイド中間体の脱水方法
Document Type and Number:
Japanese Patent JPH05504561
Kind Code:
A
Abstract:
A process for preparing oxazoline corticosteroid intermediates of formula (V) wherein R<1> represents hydrogene (H), loweralkyl, phenyl or phenylalkyl; R<4> represents H or loweralkyl, preferably methyl having either the alpha or beta stereochemistry; and R<9> represents hydrogen, fluoro, chloro or loweralkyl. The process comprises contacting a compound of formula (III) herein, with (A) Vilsmeier reagent, followed by acid hydrolysis to yield the compound of formula (V); or alternatively, (B) an acid having a pKa of less than 5, to yield the compound of formula (V).
Inventors:
Karlsers, Nicholas
Garsha Subu, Soheira
Garsha Subu, Soheira
Application Number:
JP50149590A
Publication Date:
July 15, 1993
Filing Date:
November 26, 1990
Export Citation:
Assignee:
SCHERING CORPORATION
International Classes:
C07J41/00; C07J43/00; C07J21/00; (IPC1-7): C07J21/00; C07J43/00
Attorney, Agent or Firm:
Kyozo Yuasa (6 people outside)