Title:
【発明の名称】2―ヒドロキシ―3―スルフィド―3―フェニルプロパン酸の製造方法およびその製造用中間体
Document Type and Number:
Japanese Patent JPH06500105
Kind Code:
A
Abstract:
ediate compounds of formula (VI), wherein: R1 is (L)a-(CH2)b-(T)c-B; a is 0 or 1; b is 3 to 14; c is 0 or 1; L and T are independently sulfur, oxygen, CH=CH, C 3BOND C, or CH2; B is H, C1-4alkyl, ethynyl, trifluoromethyl, isopropenyl, furanyl, thienyl, cyclohexyl or phenyl unsubstituted or monosubstituted by Br, Cl, CF3, C1-4alkoxy, C1-4alkyl, methylthio or trifluoromethylthio; R2 and A are independently selected from H, CF3, C1-4alkyl, C1-4alkoxy, F, Cl, Br, I, OH, NO2 or NH2; or, when R1 and A are H, R2 is (L)a-(CH2)b-(T)c-B wherein a, b, c, L, T and B are as defined above; and M is H, Li, Na, K, NH4 or an organic ammonium cation, and their use in a process for preparing leukotriene antagonists.
Inventors:
Jermouth, Alvidus Alphonsus
Application Number:
JP51449091A
Publication Date:
January 06, 1994
Filing Date:
July 31, 1991
Export Citation:
Assignee:
SMITHKLINE BEECHAM CORPORATION
International Classes:
A61K31/42; A61K31/421; A61K31/425; A61K31/433; A61P29/00; A61P37/08; C07C319/14; C07C323/56; C07D207/333; C07D213/32; C07D231/18; C07D233/84; C07D249/04; C07D249/08; C07D249/12; C07D257/02; C07D263/32; C07D263/46; C07D277/28; C07D277/36; C07D285/02; C07D303/38; C07D303/48; C07D307/42; C07D307/64; C07D311/24; C07D333/18; C07D333/34; A61K31/395; C07D405/12; C07D407/06; C07D407/12; C07D409/06; C07D409/12; C07D417/12; (IPC1-7): C07D233/84; C07C319/14; C07C323/56; C07D207/333; C07D213/32; C07D231/18; C07D249/04; C07D249/08; C07D249/12; C07D257/02; C07D263/32; C07D263/46; C07D285/02; C07D303/38; C07D307/42; C07D307/64; C07D311/24; C07D333/18; C07D333/34; C07D405/12; C07D407/06; C07D407/12; C07D409/06; C07D409/12; C07D417/12
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)