Title:
【発明の名称】アミノ―またはアミドアルキルマレイミド、アミドアルキルマレイミドとペプチドまたはタンパク質との複合体またはヘテロ二官能性複合体の製法
Document Type and Number:
Japanese Patent JPH07110851
Kind Code:
B2
Abstract:
The invention concerns new aminoalkylmaleimides of the general formula I (I) in which R1 and R2 are the same or different and represent hydrogen or a C1-C4 alkyl group and A represents a straight-chain or branched, saturated or unsaturated alkylene group with 2 to 6 carbon atoms which is interrupted, if desired, by an oxygen or sulphur atom or a carbonyl group, as well as their corresponding acid addition salts. The present invention also concerns amidoalkylmaleimide derivatives formed from compounds of the general formula I and immunological binding partners. In addition, the invention concerns immunological conjugates which can be produced by reaction of the amidoalkylmaleimide derivatives with peptides or proteins. The subject matter of the present invention are also the corresponding processes of production of the compounds according to the present invention as well as the use of these conjugates in diagnostic methods of determination, in particular in immunoassays.
Inventors:
FUUBAA ERASUMUSU
KURAIN KURISUTEIAN
BATSUTSU HANSUUGEORUKU
TSUINKU BURUUNO
KURAIN KURISUTEIAN
BATSUTSU HANSUUGEORUKU
TSUINKU BURUUNO
Application Number:
JP50862190A
Publication Date:
November 29, 1995
Filing Date:
June 16, 1990
Export Citation:
Assignee:
BOEHRINGER MANNHEIM GMBH
International Classes:
C07D207/452; C07D239/62; C07D473/08; G01N33/531; C07J41/00; C07J43/00; C07K1/13; C07K14/00; C07K19/00; G01N33/535; G01N33/543; G01N33/547; C07D207/44; (IPC1-7): C07D207/452; C07K1/13
Domestic Patent References:
| JPS60172933A | 1985-09-06 | |||
| JPS505379A | 1975-01-21 |
Foreign References:
| EP0314042A2 | 1989-05-03 |
Attorney, Agent or Firm:
Toshio Yano (2 outside)