Title:
【発明の名称】フラボノ-リグナン調剤の製造法、この種の調剤、該調剤を含有する医薬品および該医薬品の製造法
Document Type and Number:
Japanese Patent JP2812909
Kind Code:
B2
Abstract:
The following are claimed: (A) prodn. of a flavano-lignan (FL) prepn. which has improved release properties compared to pure FL, comprising: (a1) prodn. of an aq.-alcoholic soln. of carriers and wetting agents, suspending an FL in this soln., and heating the resulting mixt. to boiling temp. to give a clear soln.; or (a2) suspending an FL and a wetting agent in alcohol, warming and stirring the suspension until a clear soln. is formed, treating this soln. with an aq. soln. of carriers, and heating and stirring the resulting mixt. until a clear soln. is formed; and (b) concentrating the clear soln. resulting from steps (a1) or (a2) until a coprecipitate is formed, then filtering and drying the coprecipitate. (B) Prepn. of a medicament for prophylactic and/or therapeutic treatment of liver disorders, comprising processing an FL prepn., which is in the form of a co-ppte. of an FL and at least one carrier (such as may be prepd. as described in (A) above) to a dosage form suitable for oral admin. Pref. the carrier is a water soluble sugar deriv. such as a mono- or disaccharide and/or a cellulose deriv. (such as sodium carboxymethyl starch, hydroxyethyl starch or carboxymethylcellulose), or is a linear polymer of 1-vinyl-2-pyrrolidone (such as polyvidone) for disperse systems. The wetting agent is polysorbate (such as polysorbate 80) or a sorbitan ester of a fatty acid.
More Like This:
Inventors:
Wilfried Wechter
Helga Tsukesuke
Helga Tsukesuke
Application Number:
JP658196A
Publication Date:
October 22, 1998
Filing Date:
January 18, 1996
Export Citation:
Assignee:
Madaus Actien Gezershaft
International Classes:
A61K9/14; A61K36/00; A61K47/32; A61K36/28; A61K47/34; A61K47/38; A61P1/16; (IPC1-7): A61K35/78; A61K35/78
Domestic Patent References:
| JP52134010A | ||||
| JP5238085B2 |
Attorney, Agent or Firm:
Toshio Yano (2 outside)