Title:
【発明の名称】細胞の低酸素症を検出するためのパーフルオロ化〔18F〕放射性同位体標識ニトロイミダゾール誘導体の製法
Document Type and Number:
Japanese Patent JP2003507354
Kind Code:
A
Abstract:
The present invention relates to chemical synthesis of radiolabelled perfluorinated bioactive compounds. More particularly, the present invention relates to radiolabelled compounds to be used as indicators for tissue hypoxia. More particularly, the present invention relates to the synthesis and the use of [18F] labelled perfluorinated nitroimidazole compounds having an incorporation of [18F] atoms characterized by a specific radioactivity of the compound comprised between 1 and 30 Ci/mmol, preferably between 1 and 20 Ci/mmol, preferably 1 and 10 Ci/mmol. More particularly to [18F] labelled EF3 or [18F] labelled EF5. The present invention also relates to a method for the detection of tissue hypoxia in a patient comprising introducing an [18F] labelled nitroimidazole compound into said patient, imaging tissue hypoxia in said patient, and, quantifying tissue hypoxia in said patient.
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Inventors:
Marcian, Jacqueline
Gregoire, Vincent
Gregoire, Vincent
Application Number:
JP2001516877A
Publication Date:
February 25, 2003
Filing Date:
May 22, 2000
Export Citation:
Assignee:
Université Catholic de Reuben
International Classes:
G01N33/48; A61K51/00; C07B39/00; C07B59/00; C07B61/00; C07C211/03; C07D209/48; C07D233/91; C07D409/06; G01N33/58; (IPC1-7): C07D233/91; A61K51/00; C07B39/00; C07B59/00; C07D209/48; C07D409/06; G01N33/48
Domestic Patent References:
| JPH08503469A | 1996-04-16 |
Foreign References:
| US3532755A | 1970-10-06 |
Attorney, Agent or Firm:
Hajime Tsukuni (1 person outside)