Title:
【発明の名称】カルシウムレセプター活性化合物のスクリーニング方法
Document Type and Number:
Japanese Patent JP2887201
Kind Code:
B2
Abstract:
Method and composition useful for treating a patient having a disease characterized by an abnormal level of one or more components, the activity of which is regulated or affected by activity of one or more Ca2+ receptors. Novel compounds useful in these methods and compositions are also provided. The method includes administering to the patient a therapeutically effective amount of a molecule active at one or more Ca2+ receptors as an agonist or antagonist. Preferably, the molecule is able to act as either a selective agonist or antagonist at a Ca2+ receptor of one or more but not all cells chosen from the group consisting of parathyroid cells, bone osteoclasts, juxtaglomerular kidney cells, proximal tubule kidney cells, keratinocytes, parafollicular thyroid cells and placental throphoblasts and a pharmaceutically acceptable carrier.
Inventors:
NEMESU EDOWAADO EFU
UAN UEIJINEN BURATSUDOFUOODO SHII
BARANDORIN MANYUERU EFU
UAN UEIJINEN BURATSUDOFUOODO SHII
BARANDORIN MANYUERU EFU
Application Number:
JP23216596A
Publication Date:
April 26, 1999
Filing Date:
September 02, 1996
Export Citation:
Assignee:
ENU PII ESU PHARM INC
International Classes:
G01N33/15; A61K31/13; A61K31/135; A61K31/14; A61K31/16; A61K31/165; A61K31/235; A61K31/275; A61K31/395; A61K31/40; A61K31/403; A61K31/404; A61K31/44; A61K31/55; A61K31/554; A61K31/715; A61K31/785; A61K33/06; A61K38/00; A61K38/16; A61K45/00; A61P3/00; A61P3/14; A61P5/18; A61P5/22; A61P9/00; A61P9/12; A61P19/08; A61P19/10; A61P43/00; C07C211/02; C07C211/03; C07C211/15; C07C211/16; C07C211/17; C07C211/19; C07C211/26; C07C211/27; C07C211/29; C07C211/30; C07C211/42; C07C215/46; C07C215/48; C07C215/50; C07C215/52; C07C217/54; C07C217/56; C07C217/58; C07C217/60; C07C219/14; C07C225/16; C07C229/38; C07C233/05; C07C235/34; C07C235/44; C07C237/22; C07C237/30; C07C255/24; C07C255/45; C07C255/58; C07C279/14; C07C323/18; C07C323/32; C07D209/14; C07D209/16; C07D209/18; C07D209/30; C07D209/40; C07D211/90; C07D213/28; C07D213/36; C07D213/38; C07D215/12; C07D215/14; C07D233/54; C07D257/02; C07D281/10; C07D295/00; C07D413/04; C07H21/00; C07K5/00; C07K7/00; C07K14/435; C07K14/705; C08G69/10; C12N5/10; C12N15/09; C12N15/12; C12Q1/02; G01N33/50; G01N33/566; G01N33/567; G01N33/574; G01N33/68; G01N33/84; C12R1/91; A61K; G01N; (IPC1-7): C12Q1/02; G01N33/566
Other References:
CELL CALCIUM=1990
Attorney, Agent or Firm:
Kazuo Shamoto (5 outside)