Title:
【発明の名称】治療剤をスクリーニングする方法
Document Type and Number:
Japanese Patent JP2002506613
Kind Code:
A
Abstract:
The invention relates to a method for screening therapeutic agents for use in combating diseases associated with gene regulation by one or more Smad proteins and TGFbeta or activin, said method comprising detecting or assaying the extent or result of transcriptional activity or binding in the presence of said agent between a Smad protein or a DNA binding fragment thereof and a double strand oligonucleotide comprising the sequence 5' WXYCAGACZ 3' or a functional equivalent thereof, wherein in said nucleotide sequence W represents A or G, X represents G or T, Y represents C, A, G or T and Z represents A or C. Also claimed are therapeutic agents identified by such a method and their use in combating diseases associated with abnormal expression of Smad-mediated TGFbeta-induced genes.
Inventors:
Gaucher, Jean-Michel
Yue, Stephane
Danre, Sylvian Gabriele Nadine
Yue, Stephane
Danre, Sylvian Gabriele Nadine
Application Number:
JP2000530630A
Publication Date:
March 05, 2002
Filing Date:
February 04, 1999
Export Citation:
Assignee:
GLAXO GROUP LIMITED
International Classes:
A61K31/277; A61K45/00; A61P7/00; A61P17/00; A61P19/00; A61P25/00; A61P35/00; A61P37/00; C12N15/09; C12N15/113; C12Q1/68; C12Q1/6897; A61K38/00; (IPC1-7): C12N15/09; A61K45/00; A61P7/00; A61P17/00; A61P19/00; A61P25/00; A61P35/00; A61P37/00; C12Q1/68
Attorney, Agent or Firm:
Takehiko Suzue (4 outside)