【発明の名称】変異株仮性狂犬病ウィルス及びそれを含有するワクチン

Japanese Patent JPH05501950

A

The invention relates to a pseudorabies virus (PRV) not found in nature and having a genome containing a mutation in the protein kinase gene region and/or in the 28K gene region. The mutation is e.g. a nucleic acid substitution, deletion, insertion or inversion, or a combination thereof. The mutations are introduced, by genetic engineering techniques, into the genome of a naturally occuring PRV, preferably NIA-3. Insertions may be nucleic acid sequences encoding antigenic polypeptides characteristic of a pathogen found in pigs. The invention also relates to vaccines containing a pseudorabies virus according to the invention, and to a process for preparing such vaccines.

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Dwint Niels
Fanzile Maria Madeleine
Halekens Arnold Leonard Joseph
Bernese Antonius Joseph Maria

JP51150490A

April 15, 1993

August 17, 1990

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Stiffing Fold Tefnis He Wettens Happen

A61K39/245; C07K14/03; C12N7/00; C12N9/12; C12N15/00; C12N15/09; C12N15/869; A61K38/00; A61K39/00; (IPC1-7): A61K39/245; C12N7/01; C12N15/38; C12N15/86

Minoru Nakamura (7 outside)

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