【発明の名称】新規なエストラジオ-ル結合体とその製造方法及び抗腫瘍剤

Title:

【発明の名称】新規なエストラジオ-ル結合体とその製造方法及び抗腫瘍剤

Document Type and Number:

Japanese Patent JPS5810394

Kind Code:

B2

Abstract:

NEW MATERIAL:An addition compound of formula composed of an estradiol derivative and streptozotocin. USE:Anti-tumor agent having selectivity to cancer cells having receptors, and low side effects. Especially effective to breast cancer, solenoma, prostatic cancer, nephritic cancer, thyroid cancer, etc. PROCESS:The objective compound of the formula is prepared by reacting the 17-OH group of estradiol with a functional group-introducing agent (e.g. monobromoacetyl bromide) to afford estradiol-17-monobromoacetate, reacting the product with alpha- benzyl-N-benzyloxycarbonyl-D-glycosamine uronate silver salt (an anti-tumor agent) at 0-100 deg.C for 2-74 hours, and finally reacting the product with H2, CH3NCO and HNO2.

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Inventors:

ASANO YOSHIRO
TAMURA FUMIO
TANAKA HIROMITSU
ENOMOTO SATOSHI

Application Number:

JP9879678A

Publication Date:

February 25, 1983

Filing Date:

August 14, 1978

Export Citation:

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Assignee:

KUREHA CHEMICAL IND CO LTD

International Classes:

A61K31/704; A61P35/00; C07J1/00; C07J41/00; C07J43/00; (IPC1-7): C07J41/00; A61K31/705

Attorney, Agent or Firm:

Yoshio Kawaguchi

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