Title:
【発明の名称】安息香酸誘導体の新規製造法
Document Type and Number:
Japanese Patent JP3001632
Kind Code:
B2
Abstract:
Prepn. of a benzoic acid of formula (V) comprises (a) subjecting an acetanilide of formula (I) and a 1,4-dihalobutane deriv. of formula (II) to a Friedel-Crafts reaction to give a 1,2,3,4-tetrahydro-6-amido- naphthalene cpd. of formula (III); (b) reacting (III) with a monoester halide of terephthalic acid to give a benzoic acid ester of formula (IV); and (c) hydrolysing (IV). R1 = lower alkyl or aryl; R2 = H or lower alkyl; R3-R6 = lower alkyl; R7 = H or lower alkyl; X = halo; R8 = lower alkyl; R9 = H or lower alkyl. - Also claimed is 4-((5,6,7,8-tetra hydro-5,5,8,8- tetramethyl-2-naphthalenyl) carbamoyl benzoic acid with a X-ray diffraction pattern given in the claims.
Inventors:
Yoshinori Hamada
Isamu Yamada
Masao Uenaka
Teruo Sakata
Isamu Yamada
Masao Uenaka
Teruo Sakata
Application Number:
JP50585291A
Publication Date:
January 24, 2000
Filing Date:
March 15, 1991
Export Citation:
Assignee:
Koichi Shuto
International Classes:
A61K9/127; A61K31/165; A61K31/00; A61K31/196; A61P3/00; C07C231/12; C07C231/14; C07C231/24; C07C233/04; C07C233/07; C07C233/11; C07C233/65; C07C235/84; (IPC1-7): C07C233/65; C07C231/24
Domestic Patent References:
| JP6176440A |
Attorney, Agent or Firm:
Masazumi Imamura (2 outside)