【発明の名称】新種トリポクラディウム・バリウム、及びそれを利用するサイクロスポリン系抗生物質の生産方法

Japanese Patent JPH0763356

B2

The invention relates to a microbial process for the production of immunosuppressive cyclosporine antibiotic complex or of its components, cyclosporine A, cyclosporine B and cyclosporine C, by the aerobic fermentation of a filamentous fungus strain biosynthesizing the above antibiotic(s) in a nutrient medium containing utilizable carbon and nitrogen sources as well as mineral salts, and by isolating the products formed, which comprises culturing a strain of the novel Tolypocladium varium fungus species producing the cyclosporine antibiotic complex, preferably tolypocladium varium sp. nov. CY/93, deposited at the National Collection of Agricultural and Industrial Microorganisms, Budapest, Hungary under the number NCAIM(P)F 001005, on a nutrient medium containing carbon sources, organic and inorganic nitrogen sources as well as mineral salts, under aerobic conditions, at 25 DEG to 30 DEG C., and, if desired, isolating and purifying the cyclosporine antibiotic complex or its components produced.

Antonia Ecker Nehe Bocagne
Garbol am bursch
Eva Tote Chardi
Istvan Mihai Servo
Agota hülberne edbosch
Attila Andhru
Carroy albrecht
Karlman Kenzel
Valeria cell
Eva Tomorine Yeosto
Imre Moravchik
Karlman Poiya
Janos Erdi
Layoche quiche
Carroy naji
Bella Parrotash
Etelka Delineae Consky
Carroy beetle
Aniko Mornar Nehe Antal
Gyorgy Santa
Vilma Saas Hejethy

JP32852989A

July 12, 1995

December 20, 1989

Click for automatic bibliography generation  

Biogal

A61K31/545; A61K38/00; A61P37/06; C07D501/00; C07K7/64; C12P1/00; C12P21/04; C12N1/14; C12P35/00; C12R1/645; (IPC1-7): C12N1/14; C12P21/04

Soichi Takezawa

Next Patent: OIL LEAKAGE PREVENTING DEVICE FOR AIR CONDITIONING SYSTEM