Title:
【発明の名称】新規の11-アリールステロイド化合物
Document Type and Number:
Japanese Patent JP2768707
Kind Code:
B2
Abstract:
The invention relates to new 11-arylsteroid compounds, having a strong antiprogestin and a weak or nonexistent antiglucocorticoid activity, to processes for preparing said compounds and also to pharmaceutical preparations which contain these derivatives as active constituent, characterized in that said steroids have the following formula: in which R1 is an aryl group with a - @@@X group as substituent, X and Y each being separately H or a (1-4 C) hydrocarbyl group or together a (2-6 C) hydrocarbyl group which forms a 3- to 7-membered ring together with the nitrogen atom; R2 is hydrogen, hydroxyl, an acyloxy or an alkoxy group or a saturated or unsaturated hydrocarbyl group containing 1-8 carbon atoms, which hydrocarbyl group is provided with at least one hydroxyl, oxo, azido, cyano and/or halogen group; R3 is a hydroxyl, an acyloxy or an alkoxy group or an acyl group optionally substituted by a hydroxyl, alkoxy, acyloxy or halogen group; or R2 and R3 together form a ring system, with the proviso that if R3 is hydroxyl, R2 is not hydrogen or hydroxyl; and R4 is a methyl or ethyl group; and the alpha - and beta -bonds are indicated by dashed (---) and wedged ( @) lines respectively.
Inventors:
Hendrick Paul de Jong
Nicolas Pieter Juan Fleet
Nicolas Pieter Juan Fleet
Application Number:
JP31364388A
Publication Date:
June 25, 1998
Filing Date:
December 12, 1988
Export Citation:
Assignee:
Akzo Nva
International Classes:
A61K31/56; A61K31/565; A61K31/58; C07J41/00; C07J43/00; (IPC1-7): C07J41/00; A61K31/56; C07J43/00
Attorney, Agent or Firm:
Yoshio Kawaguchi (2 outside)