Title:
【発明の名称】新規抗ウイルス性置換ピリミジンジオン単素炭素環式ヌクレオシド誘導体及びその製造方法とこれを活性成分として含有する組成物
Document Type and Number:
Japanese Patent JP3049095
Kind Code:
B2
Abstract:
PCT No. PCT/KR96/00265 Sec. 371 Date Jan. 21, 1998 Sec. 102(e) Date Jan. 21, 1998 PCT Filed Dec. 30, 1996 PCT Pub. No. WO97/30979 PCT Pub. Date Aug. 28, 1997The present invention relates to novel compound of general formula (I) and pharmaceutically acceptable salts thereof, and process for the preparation of such derivatives and to pharmaceutical compositions containing the same as active ingredients. wherein R1, R2, and R3 represents independently hydrogen atom, halogen atom, C1-C10 alkyl, C1-C10 thioalkyl, C3-C8 optionally substituted cyclicalkyl, unsaturated alkyl, substituted alkyl hydroxyl or aryl hydroxyl, C1-C10 alkylamine, nitro, C1-C4 lower ester, C1-C4 lower alkoxy, C1-C4 lower thioalkoxy; Z represents oxygen atom, sulfur atom, carbon atom and carbonyl group; X represents oxygen atom, sulfur atom; n represents an integer of 1-3; and (sub)cycloalk(en)yl represents in which R4 and R5 represents independently hydrogen atom, hydroxymethyl, protected hydroxymethyl, benzyl, substituted carbonyl, substituted alkylsulfonyl or arylsulfonyl, substituted silyl or the like.
Inventors:
Cho, Eui-Huang
Chung, Sun-Gun
Kim, Jung-Young
Kwon, Ho-seok
Lee, Sun-Huang
Lee, Jae-ung
Jew, Jung-Ho
Kim, Byung-Chul
Kang, Dong-Wuk
Chung, Sun-Gun
Kim, Jung-Young
Kwon, Ho-seok
Lee, Sun-Huang
Lee, Jae-ung
Jew, Jung-Ho
Kim, Byung-Chul
Kang, Dong-Wuk
Application Number:
JP53001397A
Publication Date:
June 05, 2000
Filing Date:
December 30, 1996
Export Citation:
Assignee:
Samjin Pharmaceutical Company, Limited
International Classes:
A61K31/505; A61K31/506; A61K31/695; A61P31/12; A61P31/14; A61P31/18; C07D239/54; C07D239/60; (IPC1-7): C07D239/54; A61K31/506; A61P31/12; C07D239/60
Domestic Patent References:
| JP4283571A | ||||
| JP3223264A | ||||
| JP1503069A |
Other References:
【文献】国際公開95/18109(WO,A1)
Attorney, Agent or Firm:
Tetsuo Hodaka