Title:
【発明の名称】新規ベンゾシクロアルケンカルボン酸及びその製造方法
Document Type and Number:
Japanese Patent JPH05500518
Kind Code:
A
Abstract:
PCT No. PCT/CH91/00064 Sec. 371 Date Nov. 20, 1991 Sec. 102(e) Date Nov. 20, 1991 PCT Filed Mar. 19, 1991 PCT Pub. No. WO91/14671 PCT Pub. Date Oct. 3, 1991.The novel (S)-4-(2-bromobenzoyl)-5-hydroxy-benzocyclobutene-1-carboxylic i.e. the compound of the formula (I) in free form or in salt form, can be used as active ingredient in pharmaceutical preparations and can be prepared by a novel process, which is characterized in that racemic 4-(2-bromobenzoyl)-5-hydroxy-benzocyclobutene-1-carboxylic acid is reacted at elevated temperature with at least the equimolar amount of quinine in an alcoholic solvent for from approximately 6 to approximately 48 hours, the quinine salt of the (S)-4-(2-bromobenzoyl)-5-hydroxy-benzocyclobutene-1-carboxylic acid, precipitated in crystalline form as the direct reaction product, is separated from the reaction mixture, and the (S)-4-(2-bromobenzoyl)-5-hydroxy-benzocyclobutene-1-carboxylic acid is set free from this salt by acid treatment in a customary manner, and, if desired, this free acid is converted into a salt.
Inventors:
Von Sprehar, Andreas
Better, Hans Yurk
Better, Hans Yurk
Application Number:
JP50514691A
Publication Date:
February 04, 1993
Filing Date:
March 19, 1991
Export Citation:
Assignee:
Ciba Specialty Chemicals Holding Inc.
International Classes:
A61P29/00; A61P43/00; C07B57/00; C07C51/487; A61K31/19; C07C62/38; (IPC1-7): A61K31/19; C07B57/00; C07C51/487; C07C62/38
Attorney, Agent or Firm:
Takashi Ishida (4 others)