Title:
【発明の名称】新規な二環式化合物
Document Type and Number:
Japanese Patent JP3435404
Kind Code:
B2
Abstract:
The present invention is directed to new bicyclic compounds of the formula [I],and pharmaceutically acceptable salts thereof wherein R1, R2, R3, R4, R5, R6, R7, Q1 Q2 and Q3 are as defined in the claims. The compounds have N-myristoyltransferase inhibitory and antifungal activity.
More Like This:
Inventors:
Yuko Aoki
Keitatsu Ebiike
Toshihiko Fujii
Kenichi Kawasaki
Riu, Pingli
Maya Mabuchi
Tatsuo Otsuka
Shinji Tsujii
Keitatsu Ebiike
Toshihiko Fujii
Kenichi Kawasaki
Riu, Pingli
Maya Mabuchi
Tatsuo Otsuka
Shinji Tsujii
Application Number:
JP2000589535A
Publication Date:
August 11, 2003
Filing Date:
December 10, 1999
Export Citation:
Assignee:
Basilia Farma Sutika AG
International Classes:
A61K31/343; A61K31/422; A61K31/443; A61K31/4436; A61K31/4439; A61K31/4545; A61K31/496; A61K31/5377; A61K31/661; A61P31/10; A61P43/00; C07D307/79; C07D307/83; C07D307/85; C07D405/04; C07D405/12; C07D405/14; C07D407/12; C07D407/14; C07D413/04; C07D413/12; C07D413/14; C07D417/14; C07F9/40; C07F9/655; (IPC1-7): C07D307/79; A61P31/10; A61P43/00; C07D307/85; C07D405/12; C07D405/14; C07D413/04; C07D413/14; C07D417/14
Other References:
Ｄｅｓｃａｍｐｓ Ｍ．，Ｂｅｎｚｏｆｕｒａｎｓ．ＸＸＸＩＶ．Ｂａｓｉｃ ｅｔｈｅｒｓ ｏｆ ２，３−ｄｉｍｅｔｈｙｌ−４−ｈｙｄｒｏｘｙｂｅｎｚｏｆｕｒａｎ ａｎｄ ｔｈｅｉｒ ａｐｐａｒｅｎｔ ｓｔｒｕｃｔｕｒｅｓ．，Ｉｎｇ．Ｃｈｉｍ．，フランス，１９６７年，４９／２／２４６−２４７，ｐ３４−３８
Ｇｏｌｄｄｅｎｂｅｒｇ Ｃ．，Ｂｅｎｚｏｆｕｒａｎｓ．ＸＬＩＶ．Ｓｙｎｔｈｅｓｉｓ ｏｆ ｂｅｎｚｏｆｕｒｙｌｏｘｙａｍｉｎｏｐｒｏｐａｎｏｌｓ．，Ｃｈｉｍ．Ｔｈｅｒ．，１９７０年，５／４，ｐ２８５−２８９
Ｎａｒｅｓｈ Ｋ．Ｓａｎｇｗａｎ，Ａｎｔｉ−ａｌｌｅｒｇｉｃ ａｇｅｎｔｓ Ｉ．１，３−Ｂｉｓ−（２−ｃａｒｂｅｔｈｏｘｙ−３−ｍｅｔｈｙｌ−ｂｅｎｚｏｆｕｒａｎｙｌ−４−ｏｘｙ）−２−ｐｒｏｐａｎｏｌ ａｎｄ ｒｅｌａｔｅｄ ｄｅ，Ｅｕｒ．Ｊ．Ｍｅｄ．Ｃｈｅｍ．，１９８７年，２２／２，ｐ１５３−１５６
Ｓｕｒａｔ Ｋｕｍａｒ，１−［Ｂｅｎｚｏｆｕｒａｎｙｌｏｘｙ−＆ ｐ−（Ｃｙｃｌｏｐｅｎｔ−２−ｅｎ−１−ｙｌ／ｉｎｄｏｌｙｌ）ｐｈｅｎｏｘｙ］−３−ｓｕｂｓｔｉｔｕｔｅｄ−ａｍｉｎｏ−ｐｒｏｐａｎ−２−ｏｌｓ／ｐｒｏｐ，Ｉｎｄｉａｎ Ｊｏｕｒｎａｌ ｏｆ Ｃｈｅｍｉｓｔｒｙ，１９８３年，２２Ｂ／７，ｐ６５９−６６３
Ｓｕｒａｔ Ｋｕｍａｒ，ｐ−（Ｃｙｃｌｏｐｅｎｔｅｎｙｌ）ｐｈｅｎｏｌ ｄｅｒｉｖａｔｉｖｅｓ ａｓ ｐｏｔｅｎｔｉａｌ ｂｉｏｄｙｎａｍｉｃ ａｇｅｎｔｓ．，Ｉｎｄｉａｎ Ｊｏｕｒｎａｌ ｏｆ Ｃｈｅｍｉｓｔｒｙ，１９８８年，２５Ｂ／１，ｐ１０６−１１０
Ｇｏｌｄｄｅｎｂｅｒｇ Ｃ．，Ｂｅｎｚｏｆｕｒａｎｓ．ＸＬＩＶ．Ｓｙｎｔｈｅｓｉｓ ｏｆ ｂｅｎｚｏｆｕｒｙｌｏｘｙａｍｉｎｏｐｒｏｐａｎｏｌｓ．，Ｃｈｉｍ．Ｔｈｅｒ．，１９７０年，５／４，ｐ２８５−２８９
Ｎａｒｅｓｈ Ｋ．Ｓａｎｇｗａｎ，Ａｎｔｉ−ａｌｌｅｒｇｉｃ ａｇｅｎｔｓ Ｉ．１，３−Ｂｉｓ−（２−ｃａｒｂｅｔｈｏｘｙ−３−ｍｅｔｈｙｌ−ｂｅｎｚｏｆｕｒａｎｙｌ−４−ｏｘｙ）−２−ｐｒｏｐａｎｏｌ ａｎｄ ｒｅｌａｔｅｄ ｄｅ，Ｅｕｒ．Ｊ．Ｍｅｄ．Ｃｈｅｍ．，１９８７年，２２／２，ｐ１５３−１５６
Ｓｕｒａｔ Ｋｕｍａｒ，１−［Ｂｅｎｚｏｆｕｒａｎｙｌｏｘｙ−＆ ｐ−（Ｃｙｃｌｏｐｅｎｔ−２−ｅｎ−１−ｙｌ／ｉｎｄｏｌｙｌ）ｐｈｅｎｏｘｙ］−３−ｓｕｂｓｔｉｔｕｔｅｄ−ａｍｉｎｏ−ｐｒｏｐａｎ−２−ｏｌｓ／ｐｒｏｐ，Ｉｎｄｉａｎ Ｊｏｕｒｎａｌ ｏｆ Ｃｈｅｍｉｓｔｒｙ，１９８３年，２２Ｂ／７，ｐ６５９−６６３
Ｓｕｒａｔ Ｋｕｍａｒ，ｐ−（Ｃｙｃｌｏｐｅｎｔｅｎｙｌ）ｐｈｅｎｏｌ ｄｅｒｉｖａｔｉｖｅｓ ａｓ ｐｏｔｅｎｔｉａｌ ｂｉｏｄｙｎａｍｉｃ ａｇｅｎｔｓ．，Ｉｎｄｉａｎ Ｊｏｕｒｎａｌ ｏｆ Ｃｈｅｍｉｓｔｒｙ，１９８８年，２５Ｂ／１，ｐ１０６−１１０
Attorney, Agent or Firm:
Hajime Tsukuni (1 person outside)