Title:
【発明の名称】新規な縮合複素環化合物とこれを用いた抗喘息剤
Document Type and Number:
Japanese Patent JP3120857
Kind Code:
B2
Abstract:
A compound of general formula (I) and a pharmaceutically acceptable acid addition salt thereof, which have both bronchodilating and thromboxane A2 synthetase inhibiting actions, and are useful as antiasthmatic agent and bronchodilator, wherein (a) represents an unsaturated five- or six-membered ring with 0 or 1 nitrogen atom and 0 or 1 sulfur atom; R1 represents hydrogen, halogen, carboxyl, lower alkoxycarbonyl, nitro or lower alkoxy; R2 represents lower alkyl, cyclohexyl, (un)substituted benzyl, thienylmethyl, (un)substituted unsaturated five- or six-membered ring with 1 to 3 nitrogen atoms and 0 to 1 sulfur atom, or (un)substituted phenyl; and R3 represents lower alkyl, lower alkenyl, lower alkynyl, aralkyl, cycloalkyl, cycloalkylmethyl, acyl, acylmethyl, benzenesulfonyl, (un)substituted lower alkyl, or (b) (wherein B represents an open-chain hydrocarbon group).
Inventors:
Nobuhiro Ohi
Toshio Kuroki
Masahisa Yamaguchi
Akima Toruoka
Takaki Koga
Kenji Kamei
Toshio Kuroki
Masahisa Yamaguchi
Akima Toruoka
Takaki Koga
Kenji Kamei
Application Number:
JP50401991A
Publication Date:
December 25, 2000
Filing Date:
February 19, 1991
Export Citation:
Assignee:
Chugai Pharmaceutical Co., Ltd.
International Classes:
C07D401/04; C07D409/04; C07D471/04; C07D495/04; (IPC1-7): C07D403/06; A61K31/502; A61K31/503; A61K31/506; A61P11/06; C07D401/04; C07D401/14; C07D403/04; C07D403/14; C07D405/14; C07D409/14; C07D417/04; C07D417/14; C07D471/04; C07D495/04; C12N9/99
Other References:
【文献】Chemical Abstracts,vol.110,要約番号212739
Attorney, Agent or Firm:
Kazuo Shamoto (4 outside)