Title:
【発明の名称】新規なクリプトフィシン
Document Type and Number:
Japanese Patent JPH11507636
Kind Code:
A
Abstract:
A cryptophycin compound is provided having the structure: Further provided are methods for producing novel cryptophycins from the Nostoc sp. of blue-green algae (cyanobacteria). Pharmaceutical compositions comprising novel cryptophycins are also provided, as are methods for using cryptophycins to inhibit the proliferation of hyperproliferative cells. Further provided are methods for using cryptophycins to inhibit the proliferation of hyperproliferative cells with drug resistant phenotypes, and to treat pathological conditions, such as neoplasia.
Inventors:
Moore, Richard E.
Smith, Charles Dee.
Patterson, Gregory M. El.
Muberry, Susan El.
Corbett, Thomas Eich.
Valerie, Frederick A.
Gorakoti, Trimrutor
Smith, Charles Dee.
Patterson, Gregory M. El.
Muberry, Susan El.
Corbett, Thomas Eich.
Valerie, Frederick A.
Gorakoti, Trimrutor
Application Number:
JP50193897A
Publication Date:
July 06, 1999
Filing Date:
June 07, 1996
Export Citation:
Assignee:
University of Hawaii
Wayne State University
Wayne State University
International Classes:
A61K31/395; C07D273/00; C07D307/20; C07D413/06; (IPC1-7): C07D273/08; A01N63/02; A61K31/395; C12P13/02; C12P17/14
Attorney, Agent or Firm:
Akira Asamura (3 outside)