Title:
【発明の名称】ノイラミン酸の新規誘導体
Document Type and Number:
Japanese Patent JPH08502953
Kind Code:
A
Abstract:
Provided are new derivatives of neuraminic acid of formula (I), where Ac represents an acyl residue of an aliphatic, araliphatic, aromatic, alicyclic, or heterocyclic carboxylic acid, including carboxylic amides, their 2-hydrocarbyl-glycosides, and their peracylated derivatives at the hydroxy groups of both these series of amides. These compounds are therapeutically useful in providing a protective effect against the neurotoxicity induced by excitatory amino acids, and can therefore be used in therapies of the central nervous system following cerebral degenerations or lesions, metabolic dysfunctions, aging, and toxic-infective and chronic neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington's diseases.
Inventors:
Romeo, Aurelio
Kirchner, Guntel
Maneb, Hari
Trimarco, Martino
Tofano, Gino
Kirchner, Guntel
Maneb, Hari
Trimarco, Martino
Tofano, Gino
Application Number:
JP50552493A
Publication Date:
April 02, 1996
Filing Date:
August 03, 1993
Export Citation:
Assignee:
Fidia Societa Pell Ationi
International Classes:
A61K31/70; A61K31/7012; C07H7/027; A61P9/10; A61P25/00; A61P25/28; C07H13/04; C07H13/06; C07H13/08; C07H13/10; C07H15/04; C07K5/06; C07K9/00; A61K38/00; (IPC1-7): C07H7/027; A61K31/70
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)