Title:
【発明の名称】新規なペプチダ-ゼ阻害剤
Document Type and Number:
Japanese Patent JP2529825
Kind Code:
B2
Abstract:
This invention relates to analogs of peptidase substrates in which the amide group containing the scissile amide bond of the substrate peptide has been replaced by an activated electrophilic ketone moiety. These analogs of the peptidase substrates provide specific enzyme inhibitors for a variety of proteases, the inhibition of which will have useful physiological consequences in a variety of disease states.
Inventors:
MAIKERU KORUBU
MAIKERU JEI JANGU
JOSEFU PII BURUKAATO
FURITSUTSU II GEEHAATO
YUUJIN ERU GIROTSUKUSU
DANIERU JII SUCHIRURIN
BAANAADO NEISESU
MAIKERU JEI JANGU
JOSEFU PII BURUKAATO
FURITSUTSU II GEEHAATO
YUUJIN ERU GIROTSUKUSU
DANIERU JII SUCHIRURIN
BAANAADO NEISESU
Application Number:
JP2137186A
Publication Date:
September 04, 1996
Filing Date:
February 04, 1986
Export Citation:
Assignee:
MERRELL DOW PHARMA
International Classes:
A61K31/13; A61K31/16; A61K31/165; A61K31/195; A61K31/215; A61K31/22; A61K38/55; A61P7/02; C07K5/00; A61P7/06; A61P9/12; A61P13/02; A61P15/00; A61P17/00; A61P29/00; A61P31/04; A61P35/00; A61P43/00; C07C67/00; C07C213/00; C07C221/00; C07C225/02; C07C225/16; C07C227/00; C07C227/16; C07C227/18; C07C229/02; C07C229/04; C07C229/22; C07C229/24; C07C229/26; C07C233/01; C07C233/31; C07C237/02; C07C237/06; C07C237/12; C07C237/20; C07C237/22; C07C239/00; C07C271/06; C07C271/22; C07C273/04; C07C279/18; C07D207/16; C07D209/42; C07D498/10; C07K1/113; C07K5/02; C07K5/04; C07K5/06; C07K5/062; C07K5/08; C07K5/083; C07K5/097; C07K7/06; C07K14/81; C12N9/99; A61K38/00; (IPC1-7): C07C225/02; C07C229/02; C07C237/02; C07D207/16; C07K5/04; C07K7/06
Domestic Patent References:
| JP53119891A | ||||
| JP61218518A | ||||
| JP6034938A |
Other References:
【文献】米国特許4277395(US,A)
Attorney, Agent or Firm:
Katsuro Sasai