Title:
【発明の名称】新規なピリジル誘導体、これらの化合物を含む医薬組成物及びそれらの調製法
Document Type and Number:
Japanese Patent JP2965425
Kind Code:
B2
Abstract:
The present invention relates to novel pyridyl derivatives of the general formula in which R6 is a pyridine group which is optionally substituted in the 3- or 4-position by an alkyl group, and X, Y, A, n and R3 to R6, R7 and R8 are as defined in Claim 1, their enantiomers, and their cis- and trans-isomers, if R4 and R5 together represent a carbon-carbon bond, which derivatives have useful properties. The compounds of the above general formula I, in which R7 represents a cyano group and Y represents an alkoxy, phenoxy, alkylthio of phenylthio group, are intermediates and the other compounds have useful pharmacological properties, in particular antithrombotic effects, and at the same time the novel compounds are additionally thromboxane antagonists (TRA) and thromboxane synthesis inhibitors (TSI) and thus also inhibit the effects mediated by thromboxane. Further, these compounds also have an effect on PGE2 production in the lung and on PGD2, PGE2 and PGF2 alpha production in human platelets.
Inventors:
RAINAA SOIKA
TOOMASU MYUURAA
YOHANESU UAIZENBERUGAA
TOOMASU MYUURAA
YOHANESU UAIZENBERUGAA
Application Number:
JP33145292A
Publication Date:
October 18, 1999
Filing Date:
December 11, 1992
Export Citation:
Assignee:
DOKUTORU KAARU TOOMEE GMBH
International Classes:
A61K31/00; A61K31/41; A61K31/435; A61K31/4406; A61K31/4418; A61K31/4425; A61K31/4427; A61K31/47; A61K31/495; A61K31/535; A61K31/44; A61K31/55; A61K31/695; A61P7/00; A61P7/02; A61P9/00; A61P9/10; A61P11/00; A61P13/00; A61P13/02; A61P13/12; A61P15/00; A61P35/00; A61P35/04; A61P37/00; A61P37/08; A61P43/00; C07D213/55; C07D401/02; C07D401/06; C07D401/12; C07D413/12; C07F7/08; C07F7/10; (IPC1-7): C07D213/55; A61K31/00; A61K31/44; A61K31/47; A61K31/495; A61K31/535; A61K31/695; C07D401/12; C07F7/10
Domestic Patent References:
| JP7504687A |
Attorney, Agent or Firm:
Minoru Nakamura (7 outside)