Title:
【発明の名称】増強剤としての新規なステロイドカルバメート
Document Type and Number:
Japanese Patent JP2000503985
Kind Code:
A
Abstract:
Novel potentiating steroid carbamates having the general formula (I) ST-OCONR1R2(I) wherein ST is a steroid or steroid derivative, of the structure (II) optionally containing double bonds and additional oxygen substituents; the carbamate moiety OCONR1R2 has lipophilic properties and is selected from N,N-dibutylcarbamate, N-(3-morpholin-4-yl-propyl)-carbamate, 4-benzyl-piperazine-1-carboxylic acid ester, N-(3-dibutylamino-propyl)-carbamate, N,N-dipropyl-carbamate, N-hexyl-carbamate, N-(1-benzyl-piperidine-4-yl)-carbamate, N-cyclohexylmethyl-carbamate, N-butyl-N-ethyl-carbamate, N-benzyl-carbamate, N-(3-dibenzazepin-1-yl-propyl)-N-methyl-carbamate, N-naphtalen-1-yl-methyl-carbamate, N-diphenylmethyl-carbamate, N,N-dibenzyl-carbamate, 3,4-dihydro-1H-isoquinoline-2-carboxylic acid ester, N,N-dipentyl-carbamate, N,N-diisobutyl-carbamate and N,N-bis-(4-fluoro-benzyl)-carbamate; and pharmaceutically acceptable salts thereof, in combination with radiation therapy and one or more cytotoxic drugs, optionally together with a pharmaceutically acceptable carrier and, if desired, other pharmacologically acceptable agents.
Inventors:
Satish Butler
Jean-Inge Carlson
Thomas fox
Jean-Inge Carlson
Thomas fox
Application Number:
JP52676997A
Publication Date:
April 04, 2000
Filing Date:
January 17, 1997
Export Citation:
Assignee:
Satish Butler
International Classes:
A61K31/58; C07J41/00; C07J43/00; A61K31/57; (IPC1-7): C07J41/00; A61K31/57; A61K31/58; C07J43/00
Attorney, Agent or Firm:
Kazuo Shamoto (5 outside)