【発明の名称】プレグナン骨格を有する新規ステロイド,それらを含む薬理製剤及びその製造のための方法

Japanese Patent JPH07507792

A

PCT No. PCT/HU93/00035 Sec. 371 Date Dec. 8, 1994 Sec. 102(e) Date Dec. 8, 1994 PCT Filed Jun. 8, 1993 PCT Pub. No. WO93/25570 PCT Pub. Date Dec. 23, 1993Novel, therapeutically active 21-aminosteroids of formula (I) (I) with pregnane skeleton, are disclosed wherein two of X, Y and Z are a nitrogen atom each and the third one is a methine group; R1 and R2 are independently from each other, a primary amino group bearing as substituent a branched-chain C4-8alkyl -alkenyl or -alkynyl group, or a C4-10cycloalkyl group comprising 1 to 3 ring(s) and being optionally substituted by at least one C1-3alkyl group; or R1 and R2 are each a spiro-heterocyclic secondary amino group containing at most 10 carbon atoms and optionally at least one oxygen atom as additional heteroatom; or one of R1 and R2 is an unsubstituted heterocyclic secondary amino group containing 4 to 7 carbon atoms and the other one is an above-identified primary amino group, an above-identified spiro-heterocyclic secondary amino group, or a heterocyclic secondary amino group containing 4 to 7 carbon atoms and substituted by at least one C1-4alkyl group; and n is 1 or 2, as well as their acid addition salts and pharmaceutical compositions containing these compounds.

MAHO SANDOR (HU)
TUBA ZOLTAN (HU)
GERE ANIKO (HU)
VITTAY PAL (HU)
KISS BELA (HU)
PALOSI EVA (HU)
SZPORNY LASZLO (HU)
FRANCSICSNE CZINEGE ERZSEBET (HU)
BOOR LAJOSNE DR (HU)
BALOGH GABOR (HU)
GOEROEG SANDOR (HU)

JP50131694A

August 31, 1995

June 08, 1993

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RICHTER GEDEON VEGYESZET (HU)

A61K31/58; A61P3/06; C07D239/42; A61K31/57; C07D239/48; C07D239/50; C07D491/10; C07J43/00; C07J; C07J9/00; (IPC1-7): C07J43/00; A61K31/57

Takashi Ishida (3 others)

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