Title:
【発明の名称】クロライドチャンネル遮断剤として有用なフエニル誘導体
Document Type and Number:
Japanese Patent JP2000510862
Kind Code:
A
Abstract:
The present invention relates to a method for the treatment of a disorder or disease of a living animal body, including a human, which disorder or disease is responsive to the blockade of chloride channels, comprising administering to a living animal body in need thereof a therapeutically effective amount of a compound having formula (I) or a pharmaceutically acceptable salt thereof wherein R<2>, R<3>, R<4> and R<5> are each independently selected from hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, alkoxy, hydroxy, halogen, trifluoromethyl, trifluoromethoxy, cyano, nitro, amino, and aryl, aralkyl, arylamino, aryloxy, aryl-CO-, or heteroaryl, wherein the aryl or heteroaryl group may be substituted one or more times with substituents selected from alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, hydroxy, alkoxy, halogen, trifluoromethyl, trifluoromethoxy, cyano, nitro and amino; or R<3> and R<4> or R<4> and R<5> together form a fused 4 to 7 membered carbocyclic ring which may be unsaturated, or partially or fully saturated while the other substituents R<2>, R<3>, R<4> and R<5> is as defined above; Y is -CO-, -CS-, -SO2-, or -C(=N-R<8>)-, wherein R<8> is hydrogen, alkyl, or cyano; X is -NH-, -CH2-NH-, -SO2-NH-, or -CH2-; Z is -NR<6>-, -O-, -CH=CH-, -N=CH-, -CH=N-, or -NR<6>-CH2-, wherein R<6> is hydrogen, or alkyl; R<11>, R<12>, R<13>, R<14> and R<15> are each independently selected from hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, alkoxy, hydroxy, halogen, trifluoromethyl, trifluoromethoxy, cyano, nitro, amino, and aryl, aralkyl, arylamino, aryloxy, aryl-CO-, or heteroaryl, wherein the aryl or heteroaryl group may be substituted one or more times with substituents selected from alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, hydroxy, alkoxy, halogen, trifluoromethyl, trifluoromethoxy, cyano, nitro and amino; or one of R<11> and R<12>, R<12> and R<13>, R<13> and R<14> or R<14> and R<15> together form a fused 4 to 7 membered carbocyclic ring which may be unsaturated, or partially or fully saturated while the other substituents R<11>, R<12>, R<13>, R<14> and R<15> is as defined above.
Inventors:
Christoph Erzen Palais
Pedersen Ove
Pedersen Ove
Application Number:
JP54159697A
Publication Date:
August 22, 2000
Filing Date:
May 26, 1997
Export Citation:
Assignee:
Neurosearch Actiesel Scab
International Classes:
A61K31/00; A61K31/155; A61K31/165; A61K31/17; A61K31/19; A61K31/235; A61K31/24; A61P1/00; A61P1/04; A61P1/12; A61P7/00; A61P7/06; A61P9/00; A61P9/10; A61P9/12; A61P27/00; A61P27/06; A61P29/00; A61P37/00; A61P37/08; C07C233/55; C07C271/58; C07C275/40; C07C309/51; C07C311/08; C07C311/21; C07C311/47; C07C311/60; C07C335/22; (IPC1-7): A61K31/17; A61K31/155; A61K31/165; A61K31/19; A61K31/235; A61K31/24; A61P1/04; A61P1/12; A61P7/06; A61P9/10; A61P9/12; A61P27/06; A61P29/00; A61P37/08
Attorney, Agent or Firm:
Mitsufumi Ezaki (3 others)
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