Title:
【発明の名称】46キロダルトンHMFG分化抗原結合特異性と第5及び第8凝固因子軽鎖ホモロジーとを有するポリペプチド
Document Type and Number:
Japanese Patent JPH06510981
Kind Code:
A
Abstract:
A polypeptide has the antibody binding activity of the 46K dalton HMFG differentiation antigen and/or homology to at least one of the light chains of clotting factors V and VIII and is also provided as a fusion protein with a second antigenic polypeptide. An antibody has affinity for the polypeptide of the invention or a functional fragment thereof. in vivo and in vitro methods for therapy vaccination and detecting the presence of the polypeptide, the antibody, the DNA and RNA of the invention are provided. DNA and RNA sequences encode the polypeptide of the invention or fragments thereof and immunoassay kits comprise the antibodies and/or polypeptides of the invention.
Inventors:
Seriani, Robert El.
Peterson, Jerry Arthur
Larakka, David James
Peterson, Jerry Arthur
Larakka, David James
Application Number:
JP50220792A
Publication Date:
December 08, 1994
Filing Date:
September 16, 1991
Export Citation:
Assignee:
John Muir Cancer and Research Institute
Seriani, Robert El.
Peterson, Jerry Arthur
Larakka, David James
Seriani, Robert El.
Peterson, Jerry Arthur
Larakka, David James
International Classes:
A61K31/70; A61K39/00; A61K39/395; A61K47/48; A61K48/00; A61K49/00; A61K51/10; A61P35/00; A61P37/02; C07K14/435; C07K14/47; C07K14/705; C07K14/745; C07K14/755; C07K16/00; C07K16/18; C07K16/30; C07K19/00; C12N15/02; C12N15/09; C12N15/12; C12P21/08; C12Q1/68; G01N33/53; G01N33/574; G01N33/577; A61K38/00; (IPC1-7): C07K15/06; A61K31/70; A61K39/00; A61K39/395; A61K48/00; A61K49/00; C12N15/12; C12N15/62; C12P21/08; C12Q1/68; G01N33/53; G01N33/574; G01N33/577
Attorney, Agent or Firm:
Atsushi Nakajima (2 outside)