Title:
【発明の名称】安定タンパク質コアに結合されたタンパク質ポリリガンド
Document Type and Number:
Japanese Patent JPH06502301
Kind Code:
A
Abstract:
Stable polyligands are provided by preparing fused proteins, where the fused protein comprises a ligand at one terminus and a subunit of a multimeric unit protein at the other terminus, where the fused protein is able to assemble to provide a polyligand. The polyligands find use in modulating physiological processes by inhibiting ligand induced signal transduction by surface membrane protein receptors and/or in the case of mu chain use, by complement mediated killing or any other effector functions. The molecule may be composed solely, of human components to avoid an immune response by the recipient.
Inventors:
Thrill, Jean-Paul
Application Number:
JP51662091A
Publication Date:
March 17, 1994
Filing Date:
August 22, 1991
Export Citation:
Assignee:
Center Hospitality Regional Denent
International Classes:
A61K39/395; A61K47/48; A61P37/00; C07K14/52; C07K14/55; C07K14/575; C07K16/00; C12N15/09; C12N15/62; C12P21/02; C12P21/08; A61K38/00; (IPC1-7): C12P21/02; A61K39/395; C12N15/62
Attorney, Agent or Firm:
Shoichi Ui (4 others)