Title:
【発明の名称】COX-2の選択的阻害剤としてのピリミジン誘導体
Document Type and Number:
Japanese Patent JP2003514898
Kind Code:
A
Abstract:
The invention provides the compounds of formula (I)and pharmaceutically acceptable derivatives thereof, in which:R<1 >and R<2 >are independently selected from H, C1-6 alkyl, C2-6alkenyl, C3-6alkynyl, C3-10cycloalkylC0-6alkyl or C4-12bridged cycloalkane; and R<3 >is C1-6alkyl or NH2.Compounds of formula (I) are potent and selective inhibitors of COX-2 and are of use in the treatment of pain, fever, inflammation and a variety of conditions and diseases.
Inventors:
Richard Howard Green
Charles David Hartley
Alan Naylor
Jeremy John Payne
Neil Anthony Peg
Charles David Hartley
Alan Naylor
Jeremy John Payne
Neil Anthony Peg
Application Number:
JP2001540074A
Publication Date:
April 22, 2003
Filing Date:
November 23, 2000
Export Citation:
Assignee:
GLAXO GROUP LIMITED
International Classes:
A61K31/505; A61P1/00; A61P1/02; A61P1/04; A61P3/02; A61P3/10; A61P5/00; A61P5/14; A61P9/00; A61P9/10; A61P11/16; A61P13/12; A61P15/06; A61P15/08; A61P17/00; A61P17/02; A61P17/04; A61P17/06; A61P19/02; A61P19/06; A61P21/00; A61P21/04; A61P25/00; A61P25/02; A61P25/04; A61P25/06; A61P25/08; A61P25/14; A61P25/28; A61P27/02; A61P29/00; A61P29/02; A61P31/12; A61P31/16; A61P31/18; A61P35/00; A61P35/04; A61P43/00; C07D239/42; (IPC1-7): C07D239/42; A61K31/505; A61P1/00; A61P1/02; A61P1/04; A61P3/02; A61P3/10; A61P5/00; A61P5/14; A61P9/00; A61P9/10; A61P11/16; A61P13/12; A61P15/06; A61P15/08; A61P17/00; A61P17/02; A61P17/04; A61P17/06; A61P19/02; A61P19/06; A61P21/00; A61P21/04; A61P25/00; A61P25/02; A61P25/04; A61P25/06; A61P25/08; A61P25/14; A61P25/28; A61P27/02; A61P29/00; A61P29/02; A61P31/12; A61P31/16; A61P31/18; A61P35/00; A61P35/04; A61P43/00
Attorney, Agent or Firm:
Aoyama Ryo (2 outside people)
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