Title:
【発明の名称】脳を標的とする薬剤供給用のレドックス系
Document Type and Number:
Japanese Patent JP3038715
Kind Code:
B2
Abstract:
Inclusion complexes of hydroxypropyl, hydroxyethyl, glucosyl, maltosyl or maltotriosyl derivatives of beta - or gamma -cyclodextrin with the reduced, biooxidizable, blood-brain barrier penetrating, lipoidal forms of dihydropyridine -><- pyridinium salt redox systems for brain-targeted drug delivery provide a means for stabilizing the redox systems, particularly against oxidation. The redox inclusion complexes also provide a means for decreasing initial drug concentrations in the lungs after administration of the systems, leading to decreased toxicity. In selected instances, complexation results in substantially improved water solubility of the redox systems as well.
Inventors:
Nicholas S Border
Application Number:
JP3789A
Publication Date:
May 08, 2000
Filing Date:
January 04, 1989
Export Citation:
Assignee:
UNIVERSITY OF FLORIDA
International Classes:
A61K9/22; A61K31/43; A61K31/44; A61K31/4427; A61K31/52; A61K31/522; A61K31/58; C07D473/18; A61P43/00; C07C219/28; C07C229/08; C07C233/18; C07C271/16; C07D211/90; C07D213/80; C07D213/82; C07D223/28; C07D233/74; C07D233/78; C07D243/38; C07D401/12; C07D401/14; C07D473/00; C07D499/00; C07H19/06; C07H19/073; C07J43/00; C08B37/00; C08B37/16; (IPC1-7): C07D211/90; A61K31/44; A61K31/58; A61K31/7072; C07D401/06; C07H19/073; C07J43/00
Attorney, Agent or Firm:
Shoichi Hirose