HEXAHYDRODIBENZOFURAN DERIVATIVE AND ITS PREPARATION

Title:

HEXAHYDRODIBENZOFURAN DERIVATIVE AND ITS PREPARATION

Document Type and Number:

Japanese Patent JPS6016980

Kind Code:

A

Abstract:

NEW MATERIAL:A compound shown by the formula I (R is lower alkoxy, mono- or di-substituted aralkyl, or lower alkyl) and its acid addition salt.

EXAMPLE: 1,2,3,4,4a,9b-Hexahydro-9-[ 2-hydroxy-3-( 1-methylethylamino )propoxy ]benzo[b]benzofuran.

USE: A drug useful for remedying arrhythmia, preventing angina pectoris, remedying hypertension, etc. Having β-adrenoceptive blocking action.

PREPARATION: A compound shown by the formula II is reacted with an epihalohydrin in alkali aqueous solution to give a compound shown by the formula III, and it is then reacted with a primary amine shown by the formula RNH2, to give a compound shown by the formula I . NaOH is preferably used as the alkali. The reaction of the amine is carried out in an inert solvent such as methanol, ethanol, etc. for 30minW several hours under reflux by heating.

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Inventors:

TAKEUCHI EIJI
TAKEBAYASHI MICHINORI
KUSASE YUU
SATOU SEIJI
MOCHIZUKI NOBUO
HAGIWARA SHIYUNICHI

Application Number:

JP12286183A

Publication Date:

January 28, 1985

Filing Date:

July 06, 1983

Export Citation:

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Assignee:

NIPPON SODA CO

International Classes:

C07D307/91; A61K31/34; A61K31/343; A61P25/02; (IPC1-7): A61K31/34

Attorney, Agent or Firm:

Yokoyama Yoshimi

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