Title:
【発明の名称】アスパラチルプロテアーゼインヒビターとしてのスルホンアミド誘導体
Document Type and Number:
Japanese Patent JPH10500938
Kind Code:
A
Abstract:
PCT No. PCT/US95/02420 Sec. 371 Date Apr. 1, 1996 Sec. 102(e) Date Apr. 1, 1996 PCT Filed Feb. 24, 1995 PCT Pub. No. WO95/24385 PCT Pub. Date Sep. 14, 1995This invention provides a novel class of sulfonamide compounds of formula I which are aspartyl protease inhibitors: This invention also provides pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting HIV-1 and HIV-2 protease activity and consequently, may be advantageously used as anti-viral agents against the HIV-1 and HIV-2 viruses. This invention also provides methods for inhibition aspartyl protease activity and methods for treating viral infections using the compounds and compositions of this invention.
Inventors:
Teng, Roger Dennis
Frances Cogerald
Daininger, David Dee.
Muko, Mark Andrew
Novak, Perry Michael
Bisseti, Govinda Lao
Frances Cogerald
Daininger, David Dee.
Muko, Mark Andrew
Novak, Perry Michael
Bisseti, Govinda Lao
Application Number:
JP52349795A
Publication Date:
January 27, 1998
Filing Date:
February 24, 1995
Export Citation:
Assignee:
VERTEX PHARMACEUTICALS INCORPORATED
International Classes:
A61K31/18; A61K31/27; A61K31/34; A61K31/341; A61K31/425; A61K31/426; A61K31/44; A61K31/4427; A61K31/445; A61K31/495; A61P31/12; A61P43/00; C07C311/16; C07C311/29; C07C311/37; C07C311/41; C07C311/51; C07D211/60; C07D213/30; C07D213/38; C07D213/40; C07D213/70; C07D213/81; C07D213/82; C07D217/24; C07D217/26; C07D231/38; C07D233/54; C07D233/76; C07D233/84; C07D233/88; C07D233/90; C07D235/06; C07D235/28; C07D241/04; C07D249/18; C07D261/08; C07D263/22; C07D263/32; C07D263/56; C07D263/58; C07D277/06; C07D277/20; C07D277/26; C07D277/36; C07D277/44; C07D277/46; C07D307/10; C07D307/20; C07D307/33; C07D309/08; C07D309/10; C07D317/18; C07D317/34; C07D319/06; C07D333/36; C07D333/38; C07D333/48; C07D335/02; C07D401/06; C07D487/04; C07D493/04; C07D521/00; (IPC1-7): C07C311/16; A61K31/18; A61K31/27; A61K31/34; A61K31/425; A61K31/44; A61K31/445; A61K31/495; C07C311/29; C07C311/37; C07C311/51; C07D211/60; C07D213/38; C07D213/40; C07D213/82; C07D277/06; C07D277/26; C07D277/36; C07D277/44; C07D307/33; C07D309/08; C07D401/06; C07D487/04; C07D493/04; C07D521/00
Attorney, Agent or Firm:
Shusaku Yamamoto