Title:
【発明の名称】味遮蔽された製剤
Document Type and Number:
Japanese Patent JP2001518490
Kind Code:
A
Abstract:
A taste-masked micromatrix powder in which the ratio of a cationic copolymer synthesized form dimethylaminoethyl methacrylate and neutral methacrylic acid esters compared to a drug having poor organoleptic properties is greater than 2 to 1, preferably 4 to 1, most preferably 6 to 1 (wt/wt). Taste masked immediate release micromatrix powders can be formed by spray drying the drug and cationic copolymer whereas sustained release micromatrix powders can be formed by granulating controlled release powders, which can be made by spray drying the drug with a retarding polymer, with the cationic copolymer. The immediate release or sustained release taste-masked powders of this invention can be incorporated into conventional oral dosage forms such as sprinkles, suspension, fast melt tablets, chewable tablets or effervescent tablets.
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Inventors:
Cumming, Kenneth Earin
Harris, Elaine Marie
Harris, Elaine Marie
Application Number:
JP2000514619A
Publication Date:
October 16, 2001
Filing Date:
September 30, 1998
Export Citation:
Assignee:
Elan Corporation PLC
International Classes:
A61K9/10; A61K9/14; A61K9/16; A61K9/20; A61K9/44; A61K9/46; A61K31/426; A61K31/4453; A61K31/557; A61K38/00; A61K38/22; A61K45/00; A61K47/32; A61P1/08; A61P7/02; A61P7/10; A61P9/00; A61P9/12; A61P25/04; A61P25/06; A61P25/20; A61P31/04; A61P35/00; A61P43/00; (IPC1-7): A61K9/16; A61K9/10; A61K9/14; A61K9/44; A61K9/46; A61K31/426; A61K31/4453; A61K31/557; A61K38/00; A61K38/22; A61K45/00; A61K47/32; A61P1/08; A61P7/02; A61P7/10; A61P9/00; A61P9/12; A61P25/04; A61P25/06; A61P25/20; A61P31/04; A61P35/00; A61P43/00
Attorney, Agent or Firm:
Kazuo Shamoto (5 outside)