Title:
【発明の名称】リン酸模倣体およびホスファターゼ阻害剤を用いる治療方法
Document Type and Number:
Japanese Patent JP2003508382
Kind Code:
A
Abstract:
The invention relates to trifluoromethyl sulfonyl and trifluoromethyl sulfonamido compounds and the physiologically acceptable salts and the prodrugs thereof. These compounds are expected to modulate the activity of protein tyrosine enzymes which are related to cellular signal transduction, in particular, protein tyrosine phosphatase, and therefore are expected to be useful in the prevention and treatment of disorders associated with abnormal protein tyrosine enzyme related cellular signal transduction such as cancer, diabetes, immuno-modulation, neurologic degenerative diseases, osteoporosis and infectious diseases. The invention also relates to the use of compounds containing fluoromethyl sulfonyl groups as phosphate mimics. These mimics may be used to inhibit, regulate or modulate the activity of a phosphate binding protein in a cell.
Inventors:
Juan Pin
Way, Chang Chen
Tan, pen and butterfly
Rian, chris
Ramfar, John
Jarrel, baiya
Bilts, John
Li, Sharon
Mattson, Matthew Neil
McMahon, Gerald
Cornig, mercer
Way, Chang Chen
Tan, pen and butterfly
Rian, chris
Ramfar, John
Jarrel, baiya
Bilts, John
Li, Sharon
Mattson, Matthew Neil
McMahon, Gerald
Cornig, mercer
Application Number:
JP2001519667A
Publication Date:
March 04, 2003
Filing Date:
August 25, 2000
Export Citation:
Assignee:
SUGEN,INC.
International Classes:
C07D295/08; A61K31/10; A61K31/18; A61K31/404; A61K31/405; A61K31/415; A61K31/4155; A61K31/416; A61K31/4184; A61K31/421; A61K31/4245; A61K31/4439; A61K31/535; A61K31/5375; A61P3/10; A61P19/10; A61P25/00; A61P31/00; A61P35/00; A61P37/00; A61P43/00; C07C311/09; C07C317/14; C07C317/22; C07C317/32; C07C317/40; C07C317/44; C07C317/50; C07C323/65; C07D209/08; C07D209/42; C07D231/22; C07D231/24; C07D235/16; C07D235/18; C07D263/32; C07D271/10; C07D295/096; C07D401/12; C07C; (IPC1-7): C07C311/09; A61K31/404; A61K31/405; A61K31/4155; A61K31/4184; A61K31/421; A61K31/4245; A61K31/4439; A61K31/5375; A61P3/10; A61P19/10; A61P25/00; A61P31/00; A61P35/00; A61P37/00; A61P43/00; C07C317/14; C07C317/22; C07C317/32; C07C323/65; C07D209/08; C07D209/42; C07D231/22; C07D235/18; C07D263/32; C07D271/10; C07D295/08; C07D401/12
Attorney, Agent or Firm:
Reiko Tanaka (1 person outside)
Previous Patent: 高脂血症の予防または治療用薬剤の製造のためのビススルホンアミドの使...
Next Patent: チオグリセロール誘導体及び光学材料のためのポリスルフィド組成物中の...
Next Patent: チオグリセロール誘導体及び光学材料のためのポリスルフィド組成物中の...