Title:
【発明の名称】新規カルバサイクリン、その製法および薬剤としてのその使用
Document Type and Number:
Japanese Patent JPS63501871
Kind Code:
A
Abstract:
Carbacycline derivatives of general formula (I), in which Y1 is the residue of Formula (II), R9 is the residue -(CH2)m-R6 or the residue -(CH2)m-o-[Z1-(CH2)m-p]x-[Z2-(CH2)m-q]y-R6, m = 2-20; o, p and q <= 19; x, y = 0, 1 or 2; Z1 is a cis-CH=CH-group, a trans-CH=CH-group or a -C=C-group, whereby each of these groups must be separated at least by one methyl group from the C-9 carbon atom of the carbacycline bi-cycle; Z2 is oxygen, sulphur, an NH or an N-methyl group, R6 is amino, methylamino, hydroxy, carboxy or mercapto; and process for their manufacture and their use as medicaments.
Inventors:
Huaburiyutsugen, Helmut
Clar, Ulrich
Bob, New Aber
Klaus-Syuttehuen, Syuteyurtz Ebecher
Clar, Ulrich
Bob, New Aber
Klaus-Syuttehuen, Syuteyurtz Ebecher
Application Number:
JP50002287A
Publication Date:
July 28, 1988
Filing Date:
November 28, 1986
Export Citation:
Assignee:
Schier Ring Actien Gezershaft
International Classes:
A61K31/557; C07C45/00; C07C49/175; C07C49/242; C07C49/83; C07C51/00; C07C59/125; C07C59/46; C07C65/01; C07C65/32; C07C67/00; C07C67/343; C07C213/00; C07C225/14; C07C225/18; C07C227/00; C07C227/06; C07C229/32; C07C229/38; C07C229/40; C07C313/00; C07C323/22; C07C323/55; C07C405/00; C07D263/00; C07D309/12; C07C69/732; (IPC1-7): A61K31/335; A61K31/38; A61K31/42; A61K31/557; C07/; C07C49/175; C07C49/242; C07C49/83; C07C59/125; C07C59/46; C07C65/01; C07C65/32; C07C67/343; C07C69/732; C07C93/20; C07C93/24; C07C93/26; C07C97/065; C07C97/10; C07C101/28; C07C101/42; C07C103/737; C07C103/76; C07C143/74; C07C149/26; C07C149/273; C07D263/12; C07D263/14
Domestic Patent References:
| JPS5215949B1 | 1977-05-06 |
Attorney, Agent or Firm:
Toshio Yano