Title:
【発明の名称】水溶性薬剤およびその製造方法
Document Type and Number:
Japanese Patent JP2002520369
Kind Code:
A
Abstract:
the present invention provides water-soluble drugs, in particular, water-soluble analogues of geldanamycin, and compositions comprising the same. This invention also provides a method of rendering water-insoluble drugs soluble in water through derivatization with a bifunctional linking molecule and subsequent conjugation to a polar moiety through a thio ether. The present invention further provides a method of treating cancer in a mammal.
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Inventors:
Ho, David Kay.
Mandler, Raya
Alvarado-Lindner, Ada Belinda
Upad Haiai, K. B. Diller
Newman, David Jay.
Mandler, Raya
Alvarado-Lindner, Ada Belinda
Upad Haiai, K. B. Diller
Newman, David Jay.
Application Number:
JP2000559871A
Publication Date:
July 09, 2002
Filing Date:
July 15, 1999
Export Citation:
Assignee:
THE UNITED STATES OF AMERICA
International Classes:
C07D225/06; A61K31/395; A61K45/00; A61K47/48; A61P35/00; C07D207/416; C07D225/02; C07D403/12; C07D207/40; (IPC1-7): A61K47/48; A61K31/395; A61K45/00; A61P35/00; C07D225/06
Domestic Patent References:
| JPH0625012A | 1994-02-01 | |||
| JPS55111469A | 1980-08-28 | |||
| JP2000509407A | 2000-07-25 | |||
| JPH1084959A | 1998-04-07 | |||
| JPH11507388A | 1999-06-29 | |||
| JPH09508792A | 1997-09-09 |
Foreign References:
| WO1998018493A2 | 1998-05-07 | |||
| WO1996040920A1 | 1996-12-19 |
Attorney, Agent or Firm:
Takashima Hajime