Title:
【発明の名称】タモキシフェン抵抗性腫瘍の処置用の非代謝性クロミフェン類似体類
Document Type and Number:
Japanese Patent JPH09500863
Kind Code:
A
Abstract:
Compounds of the formula: wherein R1 and R2 are each selected from the group consisting of C1-C2 lower alkyl; X is NH or S; and n is a whole number within the range of 1-4 inclusive; and when n=0, X is (CH2)3 and the pharmaceutically acceptable salts thereof have been shown to be effective in treating tamoxifen resistant tumors.
Inventors:
Bitoni, Alan Jay.
Baumann, Russell Jay.
Baumann, Russell Jay.
Application Number:
JP50808194A
Publication Date:
January 28, 1997
Filing Date:
August 16, 1993
Export Citation:
Assignee:
Merrell Dow Pharmaceuticals, Inc.
International Classes:
A61K31/135; A61K31/138; A61P35/00; A61P43/00; C07C211/48; C07C323/25; (IPC1-7): C07C323/25; A61K31/135
Foreign References:
| CH373975A | 1963-12-15 |
Attorney, Agent or Firm:
Katsuro Sasai