Title:
【発明の名称】白金―ポリマー錯塩および抗腫瘍剤としてのそれらの用途
Document Type and Number:
Japanese Patent JP2787241
Kind Code:
B2
Abstract:
Platinum(amine) complexes, when covalently linked to a water-soluble, biodegradable or biostable polymer, exhibit high antitumor activity at low dosages of platinum against L1210 and solid tumors. The complexes are platinum square planar complexes and octahedral structures of the formulae wherein A2 represents either 2 ammonia ligands, 2 monodentate amine ligands or a single bidentate amine ligand; P is either a biodegradable or a biostable but biocompatible polymer having pendent anionic groups which form covalent linkages with Pt; o is a positive integer and X is an anionic ligand.
Inventors:
JIRU DEBAINDAA ESU
ANDORURISU PIITAA JEI JUNIA
ANDORURISU PIITAA JEI JUNIA
Application Number:
JP50630089A
Publication Date:
August 13, 1998
Filing Date:
May 11, 1989
Export Citation:
Assignee:
ANDORURISU PHARM CORP
International Classes:
A61K31/28; A61K31/282; A61K33/243; A61P35/00; C07F15/00; C08F8/44; C08G79/00; (IPC1-7): C07F15/00; A61K31/28
Domestic Patent References:
| JP61222927A | ||||
| JP6034982A |
Other References:
【文献】米国特許4659849(US,A)
【文献】英国公開4584392(GB,A)
【文献】英国公開4584392(GB,A)
Attorney, Agent or Firm:
Michio Akaoka (1 person outside)