Title:
PRODUCTION OF 2-OXYCEPHALOSPORIN DERIVATIVE
Document Type and Number:
Japanese Patent JPS5834184
Kind Code:
A
Abstract:
PURPOSE:To obtain a 2-oxycephalosporin deriv. in high yields with extremely simple operations by electrolytically oxidizing a cephalosporin deriv. CONSTITUTION:The cerphalosporin deriv. expressed by the formulaI(e.g.; 7- phenoxyacetamide acetoxycephalosporic methyl ester) is electrolytically oxidized in the presence of generally a proton donative solvent (e.g.; acetic acid), more preferably a supporting electrolyte such as potassium acetate. Here, it is preferable to use the proton donative solvent 5-100 times the content of the cephalosporin deriv. A platinum or carbon electrode is preferable for the electrode, and the electrolysis may be effected under conditions of either constant potential or constant voltage. As a result of the electrolytic oxidation, the 2-oxycephalosporin deriv. expressed by the formula II[(e.g.;6R, 7S)-2-acetoxy-7-phenoxyacetamide acetoxycephalosporic methyl ester]is obtained. The compd. is important as a synthetic intermediate for cephalosporin type antibiotics, etc.
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Inventors:
SHIROI TAKASHI
SAITOU NORIO
SASAOKA MICHIO
TORII SHIGERU
TANAKA HIDEO
NOGAMI JIYUNZOU
SAITOU NORIO
SASAOKA MICHIO
TORII SHIGERU
TANAKA HIDEO
NOGAMI JIYUNZOU
Application Number:
JP13377481A
Publication Date:
February 28, 1983
Filing Date:
August 25, 1981
Export Citation:
Assignee:
OTSUKA KAGAKU YAKUHIN
International Classes:
C25B3/23; A61K31/545; C07D501/04; C07D501/18; C07D501/20; C07D501/22; C07D501/26; C25B3/28; (IPC1-7): C25B3/00
Attorney, Agent or Firm:
Eiji Saegusa