PERCUTANEOUS ADMINISTRATION OF PHYSIOLOGICAL ACTIVATOR USING ADJUVANT, SOLVENT AND DIOL MODULATOR

Japanese Patent JPS6013720

A

PURPOSE: To raise permeability and percutaneous absorption of physiological activator, by using a multi-component carrier system consisting of at least adjuvant (component A), at least one solvent (component B), and at least one diol modulator.

CONSTITUTION: The component A of at least one (5W24C straight-chain, branched or cyclic aliphatic hydrocarbon, 5W24C straight-chain, branched or cyclic aliphatic hydorcarbon replaced with one or more halogens, alcohol ester of 7W 18C aliphatic carboxylic acid) is blended with the component B of at least one I [thioglycerol, lactic acid or its ester, cyclic urea, compound shown by the formula I (R1WR4 are H, 1W4C lower alkyl, or 1W2C acyl), compound shown by the formula II (R5 is H, or 1W4C lower alkyl; n is 3W5), etc.] and a diol modulator, and the blend is mixed with a physiological activator, and applied to the skin. The diol mudulator reduces activity of the components A and B, and further controls the rate of absorption of the activator.

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SAITOU KENICHIROU
UIRUFURETSUDO EE SUKINAA
JIYOOJI HERAA

JP2867084A

January 24, 1985

February 20, 1984

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NITTO ELECTRIC IND CO

A61K47/22; A61K9/00; A61K9/06; A61K9/70; A61K45/08; A61K47/00; A61K47/10; A61K47/16; (IPC1-7): A61K9/70

JPS5132724A	1976-03-19
JPS58164520A	1983-09-29

Kiyotaka Sasaki

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