PURPOSE: To provide an indometacin-contg. adhesive tape excellent in percutaneous absorption and therapeutic effect and well suited to occlusive dressing for inflammatory diseases, by forming a press.-sensitive adhesive layer contg. indometacin and a penetration assistant on impermeable films.
CONSTITUTION: Indometacin and penetration assistants (e.g., glycyrrhetic acid) are mixed with a soln. of binders such as acrylate/acrylic acid copolymers or acrylate/vinyl acetate copolymers. Said mixed soln. is applied onto inpermeable films (e.g., polyethylene films, polyvinyl chloride films, polyvinyliden chloride films) to yield the intended indometacin-contg. adhesive tape. The proper amt. of indometacin or penetration assistants to be contained is about 60W400μg/cm2 or 5W100μg/cm2, respectively. Said tape is used by directly applying to inflamed skin.
WATANABE EIJI
SUZUKI SHIGEKI
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