NEW MATERIAL:The aminomaleimide of formulaI[R1 is H, 1W4C alkyl, 2W4C alkenyl, 7W10C aralkyl, or group of formula II (R2 is 1W4C alkyl or halogen; n is 0W3)].
EXAMPLE: 3-Amino-4-carbamoylmaleimide.
USE: Useful as pharmaceuticals, pesticides, and their intermediates.
PROCESS: The compound of formulaIcan be prepared by reacting the cyanoformic acid ester of formula III with the malonamide of formula IV in the presence of zinc chloride and a tert-amine preferably in a solvent such as methylene chloride, benzene, etc. at 20W100°C, and treating the resultant reaction product with an acidic aqueous solution, e.g. hydrochloric acid, p-toluenesulfonic acid, etc. at 0W30°C. The amounts of the compound of formula IV and zinc chloride are preferably ≤1/2mol and ≥1mol per 1mol of the compound of formula III, respectively.
KITA JIYUNICHIROU
FUJIMURA SUSUMU
OKIMOTO KIYOMI
JIBIKI HIROSHI
