Title:
HYDROXYMORPHINANE DERIVATIVE
Document Type and Number:
Japanese Patent JPS60185765
Kind Code:
A
Abstract:
N-substituted-14-hydroxy-3-substituted-morphinan derivatives have been found to possess potent narcotic agonist or antagonist activity. In particular, the compound N-Cyclobutylmethyl-3,14-dihydroxymorphinan has been found to possess potent agonist/antagonist activity as a non-narcotic analgesic. A new and efficient total synthesis of these compounds is described herein from the starting material 2-(p-methoxybenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline.
Inventors:
AIBO MONKOBITSUKU
KIYARORU BAACHIYANDO
HENRII UONGU
GEERII RIMU
KIYARORU BAACHIYANDO
HENRII UONGU
GEERII RIMU
Application Number:
JP1668585A
Publication Date:
September 21, 1985
Filing Date:
February 01, 1985
Export Citation:
Assignee:
BRISTOL MYERS CO
International Classes:
C07D217/20; C07D217/24; C07D221/28; C07D491/044; (IPC1-7): C07D217/24; C07D221/28
Domestic Patent References:
| JPS46191A | ||||
| JPS4834864A | 1973-05-22 |
Attorney, Agent or Firm:
Ryoji Kawase