FLUORINATED CYCLIC HEXAPEPTIDE SOMATOSTATIN ANALOG

Title:

FLUORINATED CYCLIC HEXAPEPTIDE SOMATOSTATIN ANALOG

Document Type and Number:

Japanese Patent JPS5946254

Kind Code:

A

Abstract:

Fluorinated somatostatin analogs are prepared wherein a cyclic hexapeptide contains a secondary amino acid which replaces seven of the ring amino acids of somatostatin and the Lys side chain is monofluorinated in the γ or 8 positions. The cyclic hexapeptides are easier to synthesize, have a longer duration of activity, and many have a greater level of activity than somatostatin. The compounds have the properties of inhibiting the release of glucagon, growth hormone and insulin. Certain of the compounds also are capable of inhibiting the release of gastric acid secretions. The compounds are particularly useful in the treatment of acromegaly, diabetes, diabetic retinopathy and peptic ulcers. These cyclic hexapeptides are prepared by the solid phase method.

More Like This:

WO/2008/009085	ANTI-INFLAMMATORY AND ANTIALLERGIC CYCLIC PEPTIDES
WO/2004/096840	TEMPLATE- FIXED BETA-HAIRPIN PEPTIDOMIMETICS WITH CXCR4 ANTAGONIZING ACTIVITY
JP6974661	Cyclic peptide derivative exhibiting water-soluble extract transport action

Inventors:

POORU II KAAREI
RARUFU EFU HIRUSHIYUMAN

Application Number:

JP14045783A

Publication Date:

March 15, 1984

Filing Date:

July 30, 1983

Export Citation:

Click for automatic bibliography generation Help

Assignee:

MERCK & CO INC

International Classes:

C07K7/64; A61K38/00; A61K38/04; A61P5/00; C07C67/00; C07C229/26; C07C231/00; C07C231/02; C07C231/12; C07K1/113; C07K14/575; C07K14/655; (IPC1-7): A61K37/02; A61K37/24; C07C101/24; C07C102/00; C07C103/52

Attorney, Agent or Firm:

Masao Okabe

Previous Patent: Elastic Fibers formation catalyst

Next Patent: PREPARATION OF 2-ALKOXYMETHYLENE-3,3-DIALKOXY- PROPANENITRILES